低周波磁界ばく露による神経スフェロイド内電界分布の推定

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2024/05/01

タイトル(英語): Estimation of Electric Field Inside a Neural Spheroid by Low-Frequency Magnetic Field Exposure

著者名: 齋藤　淳史（（一財）電力中央研究所 サステナブルシステム研究本部 生物・環境化学研究部門），椎名　健雄（（一財）電力中央研究所 グリッドイノベーション研究本部 ファシリティ技術研究部門），関場　陽一（（株）電力計算センター 解析技術室 系統解析部）

著者名(英語): Atsushi Saito (Biology and Environmental Chemistry Division, Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry), Takeo Shiina (Electric Facility Technology Division, Grid Innovation Research Laboratory, Central Research Institute of Electric Power Industry), Yoichi Sekiba (Power System Analysis Group, Denryoku Computing Center)

キーワード: 低周波磁界，誘導電界，刺激作用，神経スフェロイド，数値計算　　low-frequency magnetic field，induced electric field，stimulus effect，neural spheroid，numerical calculation

要約(英語): Exposure to time-varying, low-frequency and high-intensity magnetic field (MF) induce electric field (EF) inside the human body, producing stimulus effects such as nerve fiber excitation or synaptic modulation. To measure such stimulus effects by low-frequency MF expsoure in real-time, we developed a fluorescent recording system using optical fibers that is neither affected by the MF nor affects the MF distribution. In this study, a numerical calculation model composed of voxels with a 6.25 μm spatial resolution was developed. Using this numerical model, we evaluated the distribution of the EF generated inside three-dimensional neuronal tissue called neural spheroid, under 50 Hz sinusoidal wave, 300 mT (root mean square) uniform MF exposure. We also investigated the influence of the optical fiber on the electric field distribution in neural spheroid. As a result, MF produced an induced EF in the neural spheroid of more than 4 V/m, well above the theoretical threshold of synaptic modulation. These results indicated that our experimental system was suitable for the evaluation of the threshold of stimulus effects using neural spheroid.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.144 No.5 （2024） 特集：医用・生体工学関連技術

本誌掲載ページ: 411-416 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/144/5/144_411/_article/-char/ja/