脂質二重膜への超短カーボンナノチューブ挿入が及ぼす膜形態への影響

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2024/05/01

タイトル(英語): Effects of Inserting Ultrashort Carbon Nanotubes into Lipid Bilayers on Membrane Morphology

著者名: 菅野　翔一朗（東京工業大学），彭　祖癸（東京工業大学），榛葉　健太（東京大学），宮本　義孝（国立成育医療研究センター），八木　透（東京工業大学）

著者名(英語): Shoichiro Kanno (Tokyo Institute of Technology), Zugui Peng (Tokyo Institute of Technology), Kenta Shimba (The University of Tokyo), Yoshitaka Miyamoto (National Center for Child Health and Development), Tohru Yagi (Tokyo Institute of Technology)

キーワード: カーボンナノチューブ，脂質二重膜，GUV，膜変形　　carbon nanotube，lipid bilayer，GUV，membrane deformation

要約(英語): Single-walled carbon nanotubes (CNTs) are carbon materials with unique thermal, optical, mechanical, and electrical properties, with hollow cylindrical structures of a few nanometers in diameter. CNTs cut to about 10 nm (Ultrashort CNTs, US-CNTs) can spontaneously insert into lipid bilayers. Therefore, applications have been proposed to combine CNTs with lipid bilayers to give the membranes the properties of CNTs. However, CNTs interact with membranes to induce morphological changes in the membranes, which may hinder these applications. In this study, to investigate the effects, US-CNTs are exposed to lipid bilayer vesicles (giant unilamellar vesicles, GUVs), which are used as a model for cell membranes, and the changes in membrane morphology with each US-CNT concentration were evaluated by fluorescence microscopy. As a result, GUVs show morphological changes upon exposure to US-CNTs, eventually transforming into a multiple vesicle-linked shape. This result suggests an increase in the area and asymmetry of the GUV membrane. Based on these results, we have proposed a hypothesis regarding the mechanism of morphological changes induced in the GUV membranes by US-CNTs exposure.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.144 No.5 （2024） 特集：医用・生体工学関連技術

本誌掲載ページ: 424-430 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/144/5/144_424/_article/-char/ja/