脳深部刺激療法でのβ振動に基づく電気刺激波形のパルス周波数の制御

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2024/07/01

タイトル(英語): Control of Pulse Frequency of Pulsatile Stimulating Waveform on the Basis of β Oscillation in Deep Brain Stimulation

著者名: 鈴木　豪流（関東学院大学大学院工学研究科），森　亮介（関東学院大学総合研究所），元木　誠（関東学院大学大学院工学研究科），簑　弘幸（関東学院大学大学院工学研究科）

著者名(英語): Takeru Suzuki (Graduate School of Engineering, Kanto Gakuin University), Ryosuke Mori (Bulletin of Institute of Technology, Kanto Gakuin University), Makoto Motoki (Graduate School of Engineering, Kanto Gakuin University), Hiroyuki Mino (Graduate School of Engineering, Kanto Gakuin University)

キーワード: パーキンソン病，脳深部刺激療法，閉ループPI制御，Hodgkin-Huxleyモデル　　Parkinson's disease，deep brain stimulation，closed-loop PI control，Hodgkin-Huxley model

要約(英語): Deep Brain Stimulation (DBS) plays an important role as a promising clinical treatment for drug-resistant neurological and psychiatric disorders such as Parkinson's disease (PD), epilepsy, and major depression. Recently, closed-loop DBS using classical control theory such as proportional-integral (PI) control has been proposed as an on-demand stimulation strategy to reduce the power consumption of the stimulator. However, while DBS with variable pulse amplitude and constant pulse frequency has been studied, the performance of DBS with variable pulse frequency and constant pulse amplitude has not yet been clarified, leaving room for further investigation. In this study, we investigate how DBS with variable pulse frequency by PI control can suppress abnormal β oscillation derived from PD by computer simulation using a biophysical model of the cortico-basal ganglia-thalamus neural network model. Along with that, the optimal range of PI control parameter combinations was estimated. As a result, the DBS with an appropriate combination of PI control parameters suppresses the pathological β oscillation and reduces the power consumption. These results indicate that the proposed stimulating strategy with a variable pulse frequency can be applied to controlling PD induced beta power and can be more efficient than open-loop DBS using current technologies.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.144 No.7 （2024） 特集：2023年電子・情報・システム部門大会

本誌掲載ページ: 702-711 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/144/7/144_702/_article/-char/ja/