自律型インスリン投与デバイスの開発状況と将来展望（レビュー）

カテゴリ: 論文誌(論文単位)

グループ名: 【E】センサ・マイクロマシン部門

発行日: 2012/12/01

タイトル(英語): Current Development Status and Perspective of Self-Regulated Insulin Delivery Systems: A Review

著者名: 松元　亮（東京医科歯科大学　生体材料工学研究所），宮原　裕二（東京医科歯科大学　生体材料工学研究所）

著者名(英語): Akira Matsumoto (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University), Yuji Miyahara (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University)

キーワード: 高分子ゲル，フェニルボロン酸，グルコース，インスリン，糖尿病　　Polymer gels，Phenylboronic acid，Glucose，Insulin，Diabetes

要約(英語): Diabetes is not an infectious disease but its increasingly rapid and worldwide prevalence has been recognized as "pandemic". Despite the necessity for continuous and accurate glycemic control in the management of insulin dependent diabetes mellitus, the current palliative treatment relies almost solely on the patient-self injection of insulin, which not only impinges on quality of life of the patients but also fails to precisely control dose of insulin where the overdose must be strictly avoided otherwise causing serious hypoglycemia. Development of self-regulated insulin delivery systems is a long-standing challenge of materials science, for which exploitations of glucose oxidase and sugar-binding lectin are two prevalent strategies to install the function of glucose-sensitivity. These protein-based components, however, intolerant of long-term use and storage with their denaturing and cytotoxic natures, are hardly suitable for any implantable applications thus have not yet been in clinical usage to date. This review intends to provide an overview of the current efforts to develop a thoroughly synthetic alternative making use of a phenylboronic acid derivatized polyacrylamide gel.

本誌: 電気学会論文誌E（センサ・マイクロマシン部門誌） Vol.132 No.12 （2012） 特集：血糖値センサとデジタルヘルスケア

本誌掲載ページ: 455-458 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejsmas/132/12/132_455/_article/-char/ja/