グルコースにて作動する減圧機構と化学駆動・制御による人工すい臓モデルに関するレビュー

カテゴリ: 論文誌(論文単位)

グループ名: 【E】センサ・マイクロマシン部門

発行日: 2013/10/01

タイトル(英語): Review of Glucose-Driven Decompression Device for a Chemical Controlled Artificial Pancreas

著者名: 三林　浩二（東京医科歯科大学 生体材料工学研究所）

著者名(英語): Kohji Mitsubayashi (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University)

キーワード: グルコースエネルギー，バイオセンシング，糖尿病，有機エンジン，エネルギー変換，人工すい臓　　glucose energy，biosensing，diabetes，organic engine，energy conversion，artificial pancreas

要約(英語): Glucose-driven decompression device which utilizes conversion of chemical energy (glucose) to mechanical energy (actual pressure) has been developed and applied for a novel chemical controlled artificial pancreas system. The artificial system does not need to require any other power source such as electrical or mechanical energy. Integrated intermittent drug release actions and pressure changes were observed in record with CCD camera. The system was then evaluated in closed loop system setting for feedback control of the glucose concentration. The data revealed that drug release interval was extended causing stabilized constant glucose concentration on feedback effect. Accordingly, glucose concentration can be controlled autonomously similar with natural pattern of interdependent relationship between pancreas insulin secretion and glucose level. Potential applications of the organic engine include intelligent actuators, DDS (drug delivery system) and artificial muscles using biological energies (sugar, acid, lipid, etc.) with a neglibly-small heat loss.

本誌: 電気学会論文誌E（センサ・マイクロマシン部門誌） Vol.133 No.10 （2013） 特集：エネルギーの創出・活用に関わるセンシング

本誌掲載ページ: 292-296 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejsmas/133/10/133_292/_article/-char/ja/