機能性ナノ界面を有するバイオトランジスタ

カテゴリ: 論文誌(論文単位)

グループ名: 【E】センサ・マイクロマシン部門

発行日: 2013/11/01

タイトル(英語): Biotransistor with Functional Nanointerface Containing Biomolecules

著者名: 田畑　美幸（東京医科歯科大学 生体材料工学研究所），合田　達郎（東京医科歯科大学 生体材料工学研究所），松元　亮（東京医科歯科大学 生体材料工学研究所），宮原　裕二（東京医科歯科大学 生体材料工学研究所）

著者名(英語): Miyuki Tabata (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University), Tatsuro Goda (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University), Akira Matsumoto (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University), Yuji Miyahara (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University)

キーワード: バイオトランジスタ，ナノ界面，DNAシーケンシング，タンパク質，フェニルボロン酸　　Biotransistor，Nanointerface，DNA sequencing，Protein，Phenyl boronic acid

要約(英語): The convergence of nano-/bio- technology with biomedicine has occurred tremendously over the last few decades. In particular, next-generation biosensors offer great potential to treat serious medical problems in the fields of diagnostics, therapy, and drug delivery. Advantageously, an electrical biosensor platform composed of target-capturing element and semiconductor device as a signal transducer is compatible with a high-throughput analysis via miniaturization and integration into a small chip for decentralized bioanalytical applications. So far, we have successfully achieved potentiometric biosensing based mostly on a direct readout of innately charged biomolecules using field effect transistor (FET). Highly specific molecular recognition is available by constructing engineered biointerface on the sensor. Furthermore, the potentiometric technique provides the ability to perform label-free and real-time detection for various biomolecules. These features would help to promote personalized medicine for individual patients in the future. Here we describe fundamental aspects of electrical biosensing and review recent developments of the FET-based biotransistors.

本誌: 電気学会論文誌E（センサ・マイクロマシン部門誌） Vol.133 No.11 （2013）

本誌掲載ページ: B314-B319 p

原稿種別: 解説／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejsmas/133/11/133_314/_article/-char/ja/