Drop-on-demand Patterning of Microtubules by using a Needle Type Micro Dispenser

カテゴリ: 論文誌(論文単位)

グループ名: 【E】センサ・マイクロマシン部門

発行日: 2014/05/01

タイトル(英語): Drop-on-demand Patterning of Microtubules by using a Needle Type Micro Dispenser

著者名: Oya Koc （Institute of Industrial Science, The University of Tokyo）, Mehmet Cagatay Tarhan （Institute of Industrial Science, The University of Tokyo）, Yoshiyuki Kato （Applied Micro Systems Inc.）, Hiroyuki Fujita （Institute of Industrial Science, The Univer

著者名(英語): Oya Koc （Institute of Industrial Science, The University of Tokyo）, Mehmet Cagatay Tarhan （Institute of Industrial Science, The University of Tokyo）, Yoshiyuki Kato （Applied Micro Systems Inc.）, Hiroyuki Fujita （Institute of Industrial Science, The University of Tokyo）, Beomjoon Kim （Institute of Industrial Science, The University of Tokyo）

キーワード: Micro-dispenser，microtubule，kinesin，Tau protein，biosensor

要約(英語): To detect disease biomarkers in molecular level in an on-chip format, a precise patterning of functional biomolecule is crucial step of building diagnostic devices. Here, we aim at integrating a microtubule-based fluidic device to detect early state of Alzheimer's disease. Temperature or pressure-sensitive, fragile microtubule can easily depolymerize, so that it cannot be easily patterned with conventional methods, such as inkjet printing, micro contact printing, etc. For this purpose, we performed direct patterning of microtubules in 100-so tiameter by using a needle-type dispenser on fluidic device and their functionality with Kinesin motion was successfully confirmed. Overall, our results indicate that the needle type micro dispenser may pattern even fragile biomaterials in micro scale, and integrated fluidic device is promising for detecting tau protein, which is a biomarker of neurodegenerative diseases.

本誌: 電気学会論文誌E（センサ・マイクロマシン部門誌） Vol.134 No.5 （2014） 特集：平成25年度センサ・マイクロマシン部門総合研究会

本誌掲載ページ: 114-118 p

原稿種別: 論文／英語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejsmas/134/5/134_114/_article/-char/ja/