Lock-in Measurement Technique in Fluorescent Instrumentation System for Cell-based Odor Sensor

カテゴリ: 論文誌(論文単位)

グループ名: 【E】センサ・マイクロマシン部門

発行日: 2016/03/01

タイトル(英語): Lock-in Measurement Technique in Fluorescent Instrumentation System for Cell-based Odor Sensor

著者名: Totok Mujiono (Precision and Intelligent Laboratory, Tokyo Institute of Technology), Yuji Sukekawa (Precision and Intelligent Laboratory, Tokyo Institute of Technology), Takamichi Nakamoto (Precision and Intelligent Laboratory, Tokyo Institute of Technolo

著者名(英語): Totok Mujiono (Precision and Intelligent Laboratory, Tokyo Institute of Technology), Yuji Sukekawa (Precision and Intelligent Laboratory, Tokyo Institute of Technology), Takamichi Nakamoto (Precision and Intelligent Laboratory, Tokyo Institute of Technology), Hidefumi Mitsuno (Research Center for Advanced Science and Technology (RCAST), University of Tokyo), Yuko Nakajima (Research Center for Advanced Science and Technology (RCAST), University of Tokyo), Ryohei Kanzaki (Research Center for Advanced Science and Technology (RCAST), University of Tokyo), Nobuo Misawa (Electronics-Inspired Interdisciplinary Research Institute (EIIRIS), Toyohashi University of Technology)

キーワード: Biosensor，Odor sensor，Olfactory receptors，Fluorescent instrumentation，Lock-in measurement technique

要約(英語): A fluorescent instrumentation system is widely used for cell-based odor sensors. However, the fluorescent instrumentation system was easily affected by ambient light. The measurement is limited if dark conditions are required for the measurement. This paper presents the design and implementation of a lock-in measurement technique in a fluorescent instrumentation system for a cell-based odor sensor. A continuous mode of laser diode excitation was changed to a pulse mode for the purpose of modulating the fluorescent light. The ambient light asynchronous with the modulated fluorescent light can be eliminated even if the ambient light level is much higher than that of the fluorescent light. Experimental results show that using the lock-in measurement technique, the weak fluorescent signal can be extracted from a modulated signal buried under noise. We conclude that the developed fluorescent measurement system can be used to observe the concentration dependency of odorant even under ambient light conditions.

本誌: 電気学会論文誌E（センサ・マイクロマシン部門誌） Vol.136 No.3 （2016） 特集：センサ・マイクロマシン英文特集号

本誌掲載ページ: 83-89 p

原稿種別: 論文／英語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejsmas/136/3/136_83/_article/-char/ja/