微小孔アレイを通じた細胞組織の薬剤刺激と微小電極アレイによる多点電位計測

カテゴリ: 論文誌(論文単位)

グループ名: 【E】センサ・マイクロマシン部門

発行日: 2017/02/01

タイトル(英語): Chemical Stimulation of a Cellular Tissue through a Microhole Array and Multichannel Potential Measurement Using a Microelectrode Array

著者名: 大森　龍之介（九州工業大学 大学院生命体工学研究科），森迫　勇（九州工業大学 大学院生命体工学研究科），蔭山　逸行（九州工業大学 大学院生命体工学研究科），夏目　季代久（九州工業大学 大学院生命体工学研究科），安田　隆（九州工業大学 大学院生命体工学研究科）

著者名(英語): Ryunosuke Omori (Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology), Isamu Morisako (Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology), Itsuki Kageyama (Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology), Kiyohisa Natsume (Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology), Takashi Yasuda (Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology)

キーワード: 微小孔，微小電極，ダイアフラム，化学刺激，多点計測，細胞外電位　　microhole，microelectrode，diaphragm，chemical stimulation，multichannel measurement，extracellular potential

要約(英語): By forming multiple microholes and 64 microelectrodes at the center of a transparent SiN (silicon nitride) diaphragm, we developed a microdevice for chemical stimulation and multichannel measurement of extracellular potentials of cells and tissues. A rat hippocampal slice which was placed on the device was electrically stimulated using one of the 64 microelectrodes, and evoked potentials were measured at multiple areas of the slice. We chemically stimulated the slice by tetrodotoxin molecules released from the microholes, and succeeded in detecting disappearance of the potentials which was caused by inhibition of neural firing.

本誌: 電気学会論文誌E（センサ・マイクロマシン部門誌） Vol.137 No.2 （2017）

本誌掲載ページ: 59-64 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejsmas/137/2/137_59/_article/-char/ja/