改良型減圧機構を用いたグルコース駆動式薬物放出システムに関する研究

カテゴリ: 論文誌(論文単位)

グループ名: 【E】センサ・マイクロマシン部門

発行日: 2017/06/01

タイトル(英語): Glucose Driven Drug Release System Using Improved Decompression Unit

著者名: 森　大典（東京工科大学），栗原　康司（東京医科歯科大学），Munkhjargal Munkhbayar（東京医科歯科大学），當麻　浩司（東京医科歯科大学），荒川　貴博（東京医科歯科大学），矢野　和義（東京工科大学），三林　浩二（東京医科歯科大学）

著者名(英語): Daisuke Mori (Tokyo University of Technology), Koji Kurihara (Tokyo Medical and Dental University), Munkhjargal Munkhbayar (Tokyo Medical and Dental University), Koji Toma (Tokyo Medical and Dental University), Takahiro Arakawa (Tokyo Medical and Dental University), Kazuyoshi Yano (Tokyo University of Technology), Kohji Mitsubayashi (Tokyo Medical and Dental University)

キーワード: 酵素，化学・力学エネルギー変換，アクチュエータ，糖尿病，血糖値制御，薬物放出　　enzyme，chemo-mechanical energy conversion，actuator，diabetes，blood sugar control，drug release

要約(英語): In this work, an enhanced performance of an enzymatic chemo-mechanical actuator that can convert the chemical energy of glucose into mechanical energy for autonomous drug release without an electrical power is reported. The novel biochemical approach is based on increasing the decompression rate in a “vacuum unit” by fabricating enzyme co-immobilized membrane by multiple enzymes. Among the enzymes (glucose oxidase (GOD), pyranose oxidase (POD), alcohol oxidase (AOD)), which can oxidize glucose and/or glucono-1.5-lactone evaluated in co-immobilization designs within the vacuum unit, the highest decompression was obtained with POD+GOD, which was 3 times higher than that of the conventional organic engine with only GOD. Furthermore, the decompression rate of -7.4 Pa・cm3/sec in the vacuum unit necessary to drive the drug release system was obtained at 10 mmol/L glucose, which is close to the human blood sugar level. In conclusion, the vacuum unit is a promising device for development of a chemo- mechanical system driven by human blood sugar for the diabetes treatment.

本誌: 電気学会論文誌E（センサ・マイクロマシン部門誌） Vol.137 No.6 （2017） 特集：第33回「センサ・マイクロマシンと応用システム」シンポジウム受賞論文特集

本誌掲載ページ: 174-178 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejsmas/137/6/137_174/_article/-char/ja/