三次元立体露光法を用いて作製したがん細胞浸潤過程観察用マイクロ流体デバイス

カテゴリ: 論文誌(論文単位)

グループ名: 【E】センサ・マイクロマシン部門

発行日: 2018/09/01

タイトル(英語): Microfluidic Device Fabricated by Three-Dimensional Lithography for Observation of Cancer Cell Invasion Process

著者名: 立川　冴子（東京大学生産技術研究所），金田　祥平（東京大学生産技術研究所），久米村　百子（東京大学生産技術研究所），佐藤　竜偉（群馬大学），塚本　拓野（群馬大学），藤井　輝夫（東京大学生産技術研究所），鈴木　孝明（群馬大学），藤田　博之（東京大学生産技術研究所）

著者名(英語): Saeko Tachikawa (Institute of Industrial Science, The University of Tokyo), Shohei Kaneda (Institute of Industrial Science, The University of Tokyo), Momoko Kumemura (Institute of Industrial Science, The University of Tokyo), Rui Sato (Gunma University),

キーワード: マイクロ流体デバイス，がん細胞浸潤，三次元立体露光法，ソフトリソグラフィ，がん細胞凝集体　　microfluidic device，cancer cell invasion，three-dimensional lithography，soft lithography，cancer cell clusters

要約(英語): This paper describes a microfluidic device for observation of cancer cell invasion induced by chemotaxis. The developed device has two main-channels, the channel filled with cell suspension and the channel filled with solution containing chemotactic factor. These channels are connected via tapered orifice structures to capture multiple cancer cells in it to form cell clusters. Observation of cell invasions affected by cell adhesions is possible with this device. The devices were fabricated by using three-dimensional lithography and PDMS(polydimethylsiloxane) molding. Invasion cells leaving the cell clusters and moving to the channel containing chemotactic factors through the orifices were successfully observed on the device.

本誌: 電気学会論文誌E（センサ・マイクロマシン部門誌） Vol.138 No.9 （2018）

本誌掲載ページ: 435-440 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejsmas/138/9/138_435/_article/-char/ja/