微小円柱電極を用いた誘電泳動デバイスにおけるがん細胞分離特性の基礎検証

カテゴリ: 論文誌(論文単位)

グループ名: 【E】センサ・マイクロマシン部門

発行日: 2021/06/01

タイトル(英語): Basic Verification of Cancer Cell Separation Characteristics in a Dielectrophoretic Device Using a Microcylindrical Electrodes

著者名: 宮向　秀緒（東京都立大学），八木　一平（東京都立大学），内田　諭（東京都立大学），高野　雅代（（株）AFIテクノロジー），脇坂　嘉一（（株）AFIテクノロジー），円城寺　隆治（（株）AFIテクノロジー）

著者名(英語): Hideo Miyamukai (Tokyo Metropolitan University), Ippei Yagi (Tokyo Metropolitan University), Satoshi Uchida (Tokyo Metropolitan University), Masayo Takano (AFI Corporation), Yoshikazu Wakizaka (AFI Corporation), Takaharu Enjoji (AFI Corporation)

キーワード: 誘電泳動，粒子分離，ピラー電極，マイクロ流体，粒子挙動　　dielectrophoresis，particle separation，pillar electrode，microfluidics，particle behavior

要約(英語): Highly accurate isolation of circulating tumor cells (CTC) in the blood is essential for early detection of cancer. In particular, the dielectrophoretic device with a 3D structure can be expected to have separation accuracy, which cannot be obtained with conventional 2D shapes. In this study, an isolating leukemia-derived suspended Jurkat cell and fluorescent polystyrene particle, which are particles of uniform size, using a 3D microcylindrical electrodes are conducted. When the concentration of Jurkat cells was reduced to 1/100 of the concentration of polystyrene particles, Jurkat cells and polystyrene particles could be efficiently separated, and the collection efficiency at Outlet II, the outlet for the collection of target cells, was 100% and 2%, respectively. It was suggested that the proposed device may be able to separate cells of similar size with high accuracy.

本誌: 電気学会論文誌E（センサ・マイクロマシン部門誌） Vol.141 No.6 （2021）

本誌掲載ページ: 179-185 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejsmas/141/6/141_179/_article/-char/ja/