光刺激部または内視鏡観察部周囲に電極を配置したチューブ形状神経電極

カテゴリ: 論文誌(論文単位)

グループ名: 【E】センサ・マイクロマシン部門

発行日: 2022/04/01

タイトル(英語): Tube-shaped Neural Probe with Electrodes Placed Around the Optical Stimulation Area or the Endoscope Observation Area

著者名: 池田　尚人（東北大学大学院工学研究科ナノデバイス医工学分野），魯　文広（東北大学大学院工学研究科ナノデバイス医工学分野），鶴岡　典子（東北大学大学院工学研究科ナノデバイス医工学分野），虫明　元（東北大学大学院医学系研究科生体システム生理学分野），小山内　実（大阪大学大学院医学系研究科医療画像技術科学分野），大城　朝一（東北大学大学院医学系研究科生体システム生理学分野），芳賀　洋一（東北大学大学院工学研究科ナノデバイス医工学分野／東北大学大学院医工学研究科ナノデバイス医工学研究分野）

著者名(英語): Naoto Ikeda (Graduate School of Biomedical Engineering, Tohoku University), Wenguang Lu (Graduate School of Biomedical Engineering, Tohoku University), Noriko Tsuruoka (Graduate School of Biomedical Engineering, Tohoku University), Hajime Mushiake (Department of Physiology, Graduate School of Medicine, Tohoku University), Makoto Osanai (Division of Health Sciences, Graduate School of Medicine, Osaka University), Tomokazu Oshiro (Department of Physiology, Graduate School of Medicine, Tohoku University), Yoichi Haga (Graduate School of Biomedical Engineering, Tohoku University/Graduate School of Biomedical Engineering, Tohoku University)

キーワード: 神経電極，オプトジェネティクス，非平面フォトファブリケーション　　neural probe，optogenetics，nonplanar photofabrication

要約(英語): In this paper, a tube-shaped neural probe which can be combined with ultra-thin endoscope or optical fiber for optical stimulation was designed and developed. This probe is made of zirconia ceramic tube, and six electrodes were fabricated on the tip of the tube circumferentially using our developed nonplanar photofabrication process. FPC (Flexible Printed Circuit) was used for transmitting the signal from the probe to recording machine, in order not to disturb the action of a rat. The probe can be implanted in the deep brain of a rat and perform electrical recording during optical stimulation or endoscopic observation after recovery of the rat. The impedance of this probe was evaluated using three-electrodes method and in vivo test was performed using a genetically engineered rat for reaction of optical stimulation. As the result, the probe recorded neural activity of the rat at rest and after optical stimulation, and this device could be combined with the endoscope. This device may serve for optical and electrical measurement simultaneously for neuroscience researchers.

本誌: 電気学会論文誌E（センサ・マイクロマシン部門誌） Vol.142 No.4 （2022）

本誌掲載ページ: 48-55 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejsmas/142/4/142_48/_article/-char/ja/