電位計測型Solid-state biosensorの界面制御と分子認識検出

カテゴリ: 論文誌(論文単位)

グループ名: 【E】センサ・マイクロマシン部門

発行日: 2022/05/01

タイトル(英語): Control of Interface Functions for Stable Molecular Detection based on Solid-state Biosensors

著者名: 宮原　裕二（東京医科歯科大学 生体材料工学研究所），田畑　美幸（東京医科歯科大学 生体材料工学研究所）

著者名(英語): Yuji Miyahara (Tokyo Medical and Dental University (TMDU)), Miyuki Tabata (Tokyo Medical and Dental University (TMDU))

キーワード: 固体バイオセンサ，固体イオンセンサ，イオン感応膜，核酸解析，ハイブリダイゼーション_x000D_　　solid-state biosensors，solid-state ion sensors，ion-selective membrane，nucleic acid analysis，hybridization

要約(英語): We have been investigating functions of interfaces between different materials in potentiometric solid-state biosensors for stabilization of the electromotive forces (EMFs). The solid-state ion sensor showed a stable EMF only when the intermediate layer contained the primary ions and chloride ions. This indicated that an efficient ion exchange process was necessary at all interfaces involved, including a thin water layer, for a stable EMF of the solid-state ion sensor. A solid-state biosensor based on the organic and inorganic mixed phase modification of a silver surface was proposed as the second example. Stabilization of the EMF and functionalization with biomolecules on the sensing surface were simultaneously achieved using silver chloride and a self-assembled monolayer with oligonucleotide probes. The proposed schemes could be useful as stable solid-contacts for potentiometric sensor in biomedical fields such as liquid biopsy platforms and wearable sensors.

本誌: 電気学会論文誌E（センサ・マイクロマシン部門誌） Vol.142 No.5 （2022） 特集：令和3年度センサ・マイクロマシン部門総合研究会

本誌掲載ページ: 72-77 p

原稿種別: 解説／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejsmas/142/5/142_72/_article/-char/ja/