陰圧駆動可能な2層型気泡除去流路付き酵素電極センサ

カテゴリ: 論文誌(論文単位)

グループ名: 【E】センサ・マイクロマシン部門

発行日: 2023/09/01

タイトル(英語): Enzyme Electrode Sensor with Two-layer Bubble-removal Flow Channel for use Even in Negative-pressure Systems

著者名: 鶴岡　典子（東北大学大学院工学研究科），継枝　健太（東北大学大学院工学研究科），芳賀　洋一（東北大学大学院工学研究科／東北大学大学院医工学研究科）

著者名(英語): Noriko Tsuruoka (Graduate School of Engineering, Tohoku Universiry), Kenta Tsugueda (Graduate School of Engineering, Tohoku Universiry), Yoichi Haga (Graduate School of Engineering, Tohoku Universiry/Graduate School of Biomedical Engineering, Tohoku Universiry)

キーワード: 気泡除去，気泡除去器，酵素電極，疎水性多孔質膜，生体成分計測　　bubble removal，debubbler，enzyme electrode，hydrophobic porous membrane，biological substance measurement

要約(英語): In this research, an enzyme electrode sensor with a two-layer bubble-removal flow channel that can be used in a skin microperfusion system was fabricated. The first layer of the channel is placed on enzyme electrodes. The flow channel is connected to the second layer which has an outlet. A hydrophobic porous membrane is placed on the channel wall between the two layers on the inlet side of the electrodes. Thus, bubbles can bypass the electrodes by taking a shortcut through the hydrophobic porous membrane into the second layer. Since bubble removal results from the pressure difference between the layers, this flow channel can be used in both positive- and negative-pressure systems. The flow channel height and the pore size in the hydrophobic porous membrane were selected by measuring pressure differences between the two layers using different pumping methods. The bubble removal performance was evaluated during microperfusion measurements on porcine skin. In addition, the effect of the bubble-removal flow channel on lactate concentration measurements using an enzyme electrode was evaluated.

本誌: 電気学会論文誌E（センサ・マイクロマシン部門誌） Vol.143 No.9 （2023） 特集：ライフサイエンス応用のためのマイクロセンサ，センサシステムと要素技術

本誌掲載ページ: 285-292 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejsmas/143/9/143_285/_article/-char/ja/