Improvement in Sensitivity of Leakage Current Microsensor for Detection of Interaction between Liposome and Protein by Additive Denaturant

カテゴリ: 全国大会

論文No: 3-121

グループ名: 【全国大会】平成22年電気学会全国大会論文集

発行日: 2010/03/05

タイトル(英語): Improvement in Sensitivity of Leakage Current Microsensor for Detection of Interaction between Liposome and Protein by Additive Denaturant

著者名: ローチラチュンクンプリンヤー (京都工芸繊維大学),島内寿徳 (大阪大学),山下 馨(京都工芸繊維大学),馬越 大(大阪大学),久保井 亮一(大阪大学),野田 実(京都工芸繊維大学)

著者名(英語): Prinya Lorchirachoonkul(Kyoto Institute of Technology),Toshinori Shimanouchi(Osaka University),Kaoru Yamashita(Kyoto Institute of Technology),Hiroshi Umakoshi(Osaka University),Ryoichi Kuboi(Osaka University),Minoru Noda(Kyoto Institute of Technology)

キーワード: リポソーム|漏れ電流センサ|タンパク質|相互作用

要約(日本語): Sensitivity of a leakage current microsensor for detection of interaction between liposome and protein by additive denaturant. The liposome has a spherical shell shape with phospholipid membrane and the membrane property changes by interaction with external protein. The liposome entrapping ions in its cell structure releases the ions due to the interaction with the protein, and generated current by the released ions can be detected with the leakage current sensor. In this work, the authors add a denaturant of the protein to modify the interacting protein state, and detect the changed state of the protein by using the leakage current sensor.

原稿種別: 日本語

PDFファイルサイズ: 2,247 Kバイト