Characterization of Peptides-Mimetic Complementarity Determining Region of Monoclonal Antibody against TNT Using Surface Plasmon Resonance Sensor

カテゴリ: 全国大会

論文No: 3-105

グループ名: 【全国大会】平成28年電気学会全国大会論文集

発行日: 2016/03/05

タイトル(英語): Characterization of Peptides-Mimetic Complementarity Determining Region of Monoclonal Antibody against TNT Using Surface Plasmon Resonance Sensor

著者名: JIN WANG(Kyushu University),武藤 正記(Tokyo Institute of Technology),田中 祐圭(Tokyo Institute of Technology),矢田部 塁(Kyushu University),小野寺 武(Kyushu University),大河内 美奈(Tokyo Institute of Technology),都甲 潔(Kyushu University)

著者名(英語): JIN WANG(Kyushu University),Masaki Muto(Tokyo Institute of Technology),Masayoshi Tanaka(Tokyo Institute of Technology),Rui Yatabe(Kyushu University),Takeshi Onodera(Kyushu University),Mina Okochi(Tokyo Institute of Technology),Kiyoshi Toko(Kyushu University)

キーワード: ペプチド,爆薬,表面プラズモン共鳴センサ

要約(日本語): Due to the globalized terrorist acts, explosives detection has gained worldwide attention in the last decade. One of the most commonly used explosives is 2,4,6-trinitrotoluene (TNT), which results in severe effects on environment and human health. However, current sensing technologies for TNT are still far from fulfilling the requirements of sensitivity, selectivity and real-time detection. There is a great challenge to develop a technology that combines the selectivity, sensitivity and real-time detection. Here, we described a peptide for the detection of 2,4,6-trinitrotoluene using surface plasmon resonance (SPR). In this study, peptide, TNT receptor, was synthesized and selected through light and heavy chain complementarity determining regions (CDR) of TNT monoclonal antibody via amino acid sequence. The combination between peptide and TNT analogue molecule was demonstrated using surface plasmon resonance sensor.

原稿種別: 英語

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