磁気ナノ粒子の高調波特性評価と磁気粒子イメージングへの応用

カテゴリ: 論文誌(論文単位)

グループ名: 【A】基礎・材料・共通部門

発行日: 2013/06/01

タイトル(英語): Evaluation of Harmonic Signals from Magnetic Nanoparticles and Application to Magnetic Nanoparticle Imaging

著者名: 吉田　敬（九州大学），Nurmiza Binti Othman（九州大学），椿　拓也（九州大学），圓福　敬二（九州大学）

著者名(英語): Takashi Yoshida (Kyushu University), Nurmiza Binti Othman (Kyushu University), Takuya Tsubaki (Kyushu University), Keiji Enpuku (Kyushu University)

キーワード: 磁気ナノ粒子イメージング，高調波信号，非線形磁化，磁気モーメント，磁気緩和　　magnetic nanoparticle imaging，harmonic signal，nonlinear magnetization，magnetic moment，relaxation time

要約(英語): We developed a magnetic nanoparticle (MNP) imaging system that uses the harmonic signals of MNPs on the basis of their nonlinear magnetization curves. Since the interference of the excitation field can be significantly decreased by measuring the harmonic signals, the detection sensitivity can be improved. First, we have characterized the nonlinear properties of MNPs in order to evaluate the harmonic signals. We clarified what proportion of MNPs contributes to the harmonic signal. It is important to choose a sample having a large portion of MNPs with large magnetic moment and short relaxation time for the harmonic signal-based detection. Then, we measured a contour map of the signal field from the MNPs with our simple detection system using second harmonic signal. We could detect 100μg of MNPs located at z=25mm below the pickup coil with a high signal-to-noise ratio. Analyzing the contour map using a mathematical technique called singular value decomposition (SVD), we could clearly distinguish two MNP samples separated by Δx=25mm and located at z=25mm. This simple detection system will be useful for medical applications such as sentinel lymph node detection.

本誌: 電気学会論文誌A（基礎・材料・共通部門誌） Vol.133 No.6 （2013） 特集：磁気を用いた医療・医用応用技術

本誌掲載ページ: 344-350 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejfms/133/6/133_344/_article/-char/ja/