医用磁性流体を用いる電磁誘導型癌温熱療法の研究

カテゴリ: 論文誌(論文単位)

グループ名: 【A】基礎・材料・共通部門

発行日: 2013/06/01

タイトル(英語): Study on Cancer Treatment using Magnetic Fluid for Medicine and Induction Heating Device

著者名: 長江　英夫（金沢大学先端科学・イノベーション推進機構），山田　外史（金沢大学環日本海域環境研究センター），池畑　芳雄（金沢大学環日本海域環境研究センター），八木谷　聡（金沢大学理工研究域），長野　勇（金沢大学）

著者名(英語): Hideo Nagae (Organization of Frontier Science and Innovation, Kanazawa University), Sotoshi Yamada (Institute of Nature and Environmental Technology, Kanazawa University), Yoshio Ikehata (Institute of Nature and Environmental Technology, Kanazawa University), Satoshi Yagitani (Institute of Science and Engineering, Kanazawa University), Isamu Nagano (Kanazawa University)

キーワード: 超常磁性物質，電磁誘導加熱，癌治療　　superparamagnetic substance，induction heating，cancer treatment

要約(英語): Two electromagnetic heating methods have been studied in the hyperthermic treatment of cancer: dielectric heating, and induction heating using magnetic substances. Dielectric heating devices heat even normal tissues around cancer. On the other hand, induction heating has an advantage that it can heat cancer selectively. However, so far effective induction heating has been difficult: enough heat was not generated in the body because of (1) the magnetic field generated by portable induction heating devices was not strong enough, and (2) non-existence of excellent magnetic substances, and (3) strongly invasive temperature measurement in the body. In this paper, we try to solve those problems.Firstly, we develop an effective high-power induction heating device. Secondly, we obtain an excellent superparamagnetic substance known as magnetic fluid (MF) with large magnetic particles. Thirdly, we propose a detection technique of magnetic particle distribution in the body, using X-ray CT, from which the internal body temperature can be estimated. We confirm the validity of the proposed method in vitro. Finally, we do an experiment to heat the excellent MF injected into VX-2 bearing rabbits. A significant anti-cancer effect was observed. Such results suggest that our study would be quite useful for the development of induction heating hyperthermia.

本誌: 電気学会論文誌A（基礎・材料・共通部門誌） Vol.133 No.6 （2013） 特集：磁気を用いた医療・医用応用技術

本誌掲載ページ: 366-371 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejfms/133/6/133_366/_article/-char/ja/