熱応答性薬剤放出能を有するゼラチン/酸化鉄複合微粒子キャリアの作製

カテゴリ: 論文誌(論文単位)

グループ名: 【A】基礎・材料・共通部門

発行日: 2017/07/01

タイトル(英語): Synthesis of Drug Carriers Composed of Gelatin and Iron Oxide Nanoparticles with Thermally Responsive Release Capability

著者名: 大石　晟子（東京工業大学），北本　仁孝（東京工業大学）

著者名(英語): Seiko Oishi (Tokyo Institute of Technology), Yoshitaka Kitamoto (Tokyo Institute of Technology)

キーワード: 磁性微粒子，有機無機複合材料，薬剤送達システム　　magnetic nanoparticle，organic-inorganic composite material，drug delivery system

要約(英語): Many kinds of nanocarriers are attracting attention for DDS. Nanocarriers are required to have functions of loading, delivering and controlled release of drug. For this purpose, we propose and synthesize a nanocarrier by using magnetic iron oxide nanoparticles and gelatin. Iron oxide is chosen as a magnetic material because of its properties such as magnetically guided accumulation and heat generation under alternating magnetic fields as well as biodegradability. Gelatin shows sol-gel transition, which can support drugs in network structure of gel and release drugs in sol phase. To synthesize the carrier, iron oxide nanoparticles (IOPs) prepared by co-precipitation and modified with citric acid work as a cross-linker to form gelatin particles. The role of citric acid is not only improving the dispersibility of IOPs but also introducing functional groups to combine IOPs with gelatin. Concentrations of IOPs and gelatin in the solution are important parameters to control the morphology of the composite particles, leading to the formation of the particles of 50～200 nm in size under the optimum conditions. Doxorubicin as an anti-cancer drug is incorporated in the composite particles and is released by a thermal stimulation.

本誌: 電気学会論文誌A（基礎・材料・共通部門誌） Vol.137 No.7 （2017） 特集：平成28年基礎・材料・共通部門大会－テーマ付きセッション：ナノ磁性体の物性と機能性－

本誌掲載ページ: 392-397 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejfms/137/7/137_392/_article/-char/ja/