迷走神経刺激によるラット大脳皮質活動の同期度の状態依存的な調整

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2014/03/01

タイトル(英語): State-dependent Modulation of Cortical Synchrony by Vagus Nerve Stimulation in Adult Rats

著者名: 宇佐美　憲一（東京大学大学院医学系研究科脳神経外科学），狩野　竜示（東京大学大学院情報理工学系研究科知能機械情報学専攻），川合　謙介（東京大学大学院医学系研究科脳神経外科学），野田　貴大（東京大学先端科学技術研究センター），白松(磯口)　知世（東京大学大学院情報理工学系研究科知能機械情報学専攻），斉藤　延人（東京大学大学院医学系研究科脳神経外科学），高橋　宏知（東京大学大学院情報理工学系研究科知能機械情報学専攻／東京大学先端科学技術研究センター／科学技術振興機構 さきがけ）

著者名(英語): Kenichi Usami (Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo), Ryuji Kano (Department of Mechano-informatics, Graduate School of Information Science and Technology, The University of Tokyo), Kensuke Kawai (Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo), Takahiro Noda (Research Center for Advanced Science and Technology, The University of Tokyo), Tomoyo Isoguchi Shiramatsu (Department of Mechano-informatics, Graduate School of Information Science and Technology, The University of Tokyo), Nobuhito Saito (Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo), Hirokazu Takahashi (Department of Mechano-informatics, Graduate School of Information Science and Technology, The University of Tokyo/Research Center for Advanced Science and Technology, The University of Tokyo/PRESTO, JST)

キーワード: 迷走神経刺激療法，大脳皮質，局所電場電位，神経同期，位相同期，ラット　　vagus nerve stimulation，cerebral cortex，local field potential，neuronal synchrony，phase-locking，rat

要約(英語): Vagus nerve stimulation (VNS) is a palliative treatment for intractable epilepsy. Therapeutic mechanisms of VNS have not been elucidated. In this study, we measured the local field potential (LFP) with high-spatial resolution using a microelectrode array in adult rats, and analyzed VNS-induced phase modulation at a local network level. Eight adult Wistar rats (270-330 g) were used. Each rat underwent implantation of VNS system under 1.5% isoflurane anesthesia. One week after implantation, right temporal craniotomy was performed under the same as previous anesthesia. Subsequently, a microelectrode array was placed in the temporal lobe cortex, and LFP was recorded with sampling rate of 1000 Hz. Phase-locking values (PLV) between all pairs of electrodes in varied frequency bands were calculated in order to evaluate the effect of VNS in terms of synchrony of neuronal activities. PLV was calculated both in a normal state and in an epileptic state induced by kainic acid. VNS increased PLV in a normal state, particularly in the high-γ band. In an epileptic state, on the other hand, VNS increased PLV in high-γ band, and decreased PLV in the δ and low-β bands. These results suggest that VNS modulates neural activities in a band-specific and state-dependent manner so as to keep cortical synchrony within the optimal state.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.134 No.3 （2014） 特集：情報環境と人間の調和に向けた工学技術

本誌掲載ページ: 332-337 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/134/3/134_332/_article/-char/ja/