血管内皮細胞のずり応力に対するNO産生モデル

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2016/02/01

タイトル(英語): Shear Stress-induced NO Production Model of Vascular Endothelial Cell

著者名: 大橋　悠司（愛知県立大学大学院 情報科学研究科），山崎　陽一（公益財団法人 科学技術交流財団 知の拠点重点研究プロジェクト統括部），神山　斉己（愛知県立大学大学院 情報科学研究科）

著者名(英語): Yuji Ohashi (Graduate School of Information Science and Technology, Aichi Prefectural University), Yoichi Yamazaki (Priority Research Project, Aichi Science and Technology Foundation Aichi Center for Industry and Science Technology), Yoshimi Kamiyama (Graduate School of Information Science and Technology, Aichi Prefectural University)

キーワード: 動脈硬化症，血管内皮細胞，一酸化窒素（NO），電気生理学的モデル，線形特性　　Arteriosclerosis，Endothelial Cells，Nitric Oxide，Electrophysiological Model，Linear Characteristics

要約(英語): Endothelial dysfunction is known to be an early sign of arteriosclerosis. The shear stress-induced endothelial nitric oxide (NO) production is an important function of vascular system. In order to analyze this function, many in vitro experiments have been conducted and computer simulations with the mathematical models are utilized to analyze the experimental data. However, it is difficult to understand the whole function because each model simulates only a particular behavior. In this paper, we developed a multi-scale model that consists of mechanical and physiological models. This model simulates the shear stress-induced intracellular ion movements and NO synthesis. The proposed model is also able to simulate the NO production under eNOS inhibitor L-NAME. We performed the numerical experiments and demonstrated that the proposed model is capable of reproducing the experimental data of NO production. These results also suggest that the model can be used to develop a useful diagnostic application such as the estimation of in vivo NO concentration.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.136 No.2 （2016）

本誌掲載ページ: 116-122 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/136/2/136_116/_article/-char/ja/