血流依存性拡張反応時における血流シミュレーション

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2018/03/01

タイトル(英語): Blood Flow Simulation during Flow-Mediated Dilation

著者名: 浅見　直弥（愛知県立大学大学院 情報科学研究科），山﨑　陽一（関西学院大学 理工学部），神山　斉己（愛知県立大学大学院 情報科学研究科）

著者名(英語): Naoya Asami (Graduate School of Information Science and Technology, Aichi Prefectural University), Yoichi Yamazaki (School of Science and Technology, Kwansei Gakuin University), Yoshimi Kamiyama (Graduate School of Information Science and Technology, Aich

キーワード: 動脈硬化症，数理モデル，血流動態シミュレーション　　Arteriosclerosis，Mathematical Model，Hemodynamics

要約(英語): Endothelial dysfunction is known to be the early stage of arteriosclerosis. The flow-mediated dilation (FMD) test is the most commonly used method to diagnose the endothelial function. The test measures the maximum vasodilation (FMD response) on the brachial artery induced by the increases in blood flow after cuff deflation on the forearm. The vessel diameter must be captured clearly with the ultrasonic probe during the test. The vasodilation is induced in response to changes in the mechanical property of the vessel wall due to the blood flow stimulation. The changes are supposed to affect the pulsatile flow, but the influence of continuous behavior of vascular property on hemodynamics has not been clarified. In this study, in order to clarify the influence of the FMD response on hemodynamics, we propose a mathematical model that can simulate hemodynamics and vasomotor responses. As a result, it was shown that vessel wall dynamics affected the pulsatile flow. This result suggests that the endothelial function can be evaluated from blood flow.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.138 No.3 （2018） 特集：新たなセンサネットワーク社会を拓くIoT/M2M情報通信技術

本誌掲載ページ: 221-227 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/138/3/138_221/_article/-char/ja/