自発トリガーによるマイクロ血漿抽出機構の提案

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2020/04/01

タイトル(英語): Proposal of Micro Plasma Extraction Device by Autonomous Trigger Control

著者名: 内藤　大揮（山梨大学大学院医工農学総合教育部工学専攻），岡本　俊哉（山梨大学大学院医工農学総合教育部工学専攻／日本学術振興会），浮田　芳昭（山梨大学工学部機械工学科）

著者名(英語): Hiroki Naito (Department of Engineering, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, Graduate School of University of Yamanashi), Shunya Okamoto (Department of Engineering, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, Graduate School of University of Yamanashi/Japan Society for the Promotion of Science), Yoshiaki Ukita (Faculty of Engineering, Graduate Faculty of Interdisciplinary Research, Graduate School of University of Yamanashi)

キーワード: 遠心マイクロ流体デバイス，血球分離，血漿抽出，定常回転　　centrifugal microfluidics device，blood separation，plasma extraction，steady rotation

要約(英語): In this paper, we report on the development of a microfluidic device, which extract plasma from low volume whole blood (10 μL) aiming integration onto microfluidic system for micro analytical systems. The device autonomously performs separation of blood cells and transfer of separated plasma by steady rotation. Based on the original autonomous fluidic control theory, we developed the principle of automatic timed injection of pressurizing medium into the separation chamber. This realize transferring of separated plasma from blood separation chamber to other place, after separation blood cells by centrifugal force. When we demonstrated by the poly-dimethylsiloxane (PDMS) microfluidic device, it was confirmed that automatic plasma extraction was successfully implemented as designed. The efficiency of separation was evaluated from concentrations of blood cells in samples before and after extraction, and the rate of blood cells removal was 98.5%.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.140 No.4 （2020） 特集：ナノ構造の医療・バイオ応用技術

本誌掲載ページ: 437-442 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/140/4/140_437/_article/-char/ja/