金ナノ粒子二量体配列を用いたアデニン分子の高感度表面増強ラマン分光検出

カテゴリ: 論文誌(論文単位)

グループ名: 【E】センサ・マイクロマシン部門

発行日: 2016/06/01

タイトル(英語): Highly-sensitive Detection of Adenine Molecule using Surface-Enhanced Raman Spectroscopy with Gold Nanoparticle Dimer Array

著者名: 饗庭　清仁（神戸大学大学院工学研究科機械工学専攻），池上　晃平（神戸大学大学院工学研究科機械工学専攻），山崎　真之亮（神戸大学大学院工学研究科機械工学専攻），菅野　公二（神戸大学大学院工学研究科機械工学専攻），磯野　吉正（神戸大学大学院工学研究科機械工学専攻）

著者名(英語): Kiyohito Aiba (Department of Mechanical Engineering, Graduate Scool of Engineering, Kobe University), Kohei Ikegami (Department of Mechanical Engineering, Graduate Scool of Engineering, Kobe University), Shin-nosuke Yamazaki (Department of Mechanical Engineering, Graduate Scool of Engineering, Kobe University), Koji Sugano (Department of Mechanical Engineering, Graduate Scool of Engineering, Kobe University), Yoshitada Isono (Department of Mechanical Engineering, Graduate Scool of Engineering, Kobe University)

キーワード: 表面増強ラマン分光，金ナノ粒子，セルフアセンブル，ナノ粒子二量体，ナノギャップ，DNA　　Surface-enhanced Raman spectroscopy，gold nanoparticle，self-assembly，nanoparticle dimer，nanogap，DNA

要約(英語): This paper reports on highly-sensitive adenine molecule detection by surface enhanced Raman spectroscopy with single molecule sensitivity using directionally and regularly arrayed gold nanoparticle dimers with the diameter of 100 nm on the substrate. A particle dimer shows huge electromagnetic enhancement when particle connection direction is matched to polarization direction of light. In this study the dimers were arrayed by the nanotrench-guided self-assembly for generating huge total Raman enhancement. The fabricated structures were used for adenine molecule detections of 10-11 M aqueous solutions. We successfully detected the molecules at the ultra-low concentration, which indicates single molecule sensitivity. The concentration limit of detection had previously been 10-8 M in the reported literatures, which used the simple method with the prefabricated SERS substrate. Our developed substrate exhibited 103 times sensitivity. The clear peaks were found at the integration time of 0.1 s. We confirmed that our developed SERS substrate enables us to detect adenine molecules with high sensitivity and short integration time.

本誌: 電気学会論文誌E（センサ・マイクロマシン部門誌） Vol.136 No.6 （2016） 特集：第32回「センサ・マイクロマシンと応用システム」シンポジウム受賞論文特集

本誌掲載ページ: 256-260 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejsmas/136/6/136_256/_article/-char/ja/